"Toehold Switches" are widely used in synthetic biology, cell engineering, basic research, therapy development, and other applications as a novel regulator of gene expression. "Toehold Switches" are single hairpin structures with the initiation codon (AUG) hidden in a bulge and the ribosome binding site (RBS) hidden in a loop. In the absence of the target RNA present, the Toehold Switch RNA in the loop-forming structure cannot be translated. When the target RNA is present, the hairpin structure is opened and the ribosome enters, translating the attached protein-coding RNA sequence into a protein.
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