Toehold switches, as an engineered RNA element, can manipulate the translation of reporter genes. Based on this feature, toehold switches have been widely used in bacterial assays. At CD BioSciences, the toehold switches technology platform has been established and has been applied to a variety of bacterial assays. The following is a brief description of the application of toehold switches in the detection of C. difficile, E. coli, Bifidobacterium, and Bacteroides fragilis.
When the human intestinal homeostasis is altered by antibiotic stimulation, Clostridium difficile can cause diseases such as antibiotic-associated diarrhea and pseudomembranous colitis, which seriously endanger human health. Toehold switches have been demonstrated for the detection of C. difficile. CD BioSciences uses the toehold switches technology platform to provide biosensors development services and detection services for C. difficile for scholars engaged in C.
Escherichia coli is an opportunistic pathogen, which can cause infection of various organs and tissues such as the gastrointestinal tract and urinary tract in humans and various animals. Toehold switches have been confirmed to be used in the detection of E. coli. CD BioSciences uses the toehold switches technology platform to provide biosensors development services and detection services for E. coli for scholars engaged in E. coli-related research.
Bifidobacterium longum is an anaerobic, gram-positive bacteria. As beneficial microorganisms in the human gut, B. longum has various abilities such as resisting the growth of harmful bacteria, enhancing immunity, and anti-tumor. CD BioSciences uses the toehold switches technology platform to provide B. longum-specific biosensor development services and detection services for scholars engaged in B. longum-related research.
Bacteroides fragilis is an obligately anaerobic, Gram-negative bacterium. The probiotic B. fragilis can help maintain the balance of the human immune system. It can be used in various fields such as bioengineering and food. It has great potential as an alternative to antibiotics. CD BioSciences uses toehold switches technology platform to provide B. fragilis-specific biosensors development services and detection services for scholars engaged in B. fragilis related research
CD BioSciences has long focused on the application research of toehold switches. We can apply toehold switches to the detection of a variety of bacteria and provide you with corresponding services. If you are interested in our service based on toehold switches, please feel free to contact us.