Stem cells are a type of cells with self-renewal, proliferation, and differentiation capabilities. The proliferation and differentiation of stem cells provide a large number of cell sources for tissue transplantation, cell therapy, and gene therapy. Directed differentiation of stem cells plays an important role in regenerative medicine, repairing aging, damaged or diseased tissues. Stem cell directional differentiation has always been the focus of scientists' research, and the technology of inducing directional differentiation of stem cells is the key technology that determines the success of stem cells in the medical field. Therefore, the exploration of the directional differentiation technology of stem cells has never stopped.
Typically, stem cell-directed differentiation is directed by constructing a simulated cell growth microenvironment in vitro. However, the traditional in vitro culture method of stem cells needs to add a variety of growth factors to promote the proliferation and specific differentiation of stem cells. Residual growth factors may stimulate cells to grow abnormally and form tumors. To reduce the risk of cancer, some research teams started with stem cell culture materials and developed a "stem cell nano-culture device" to guide stem cells to differentiate into functional cells with therapeutic efficacy. Given the importance of stem cell differentiation, an efficient and non-carcinogenic risk-free technique for directional induction of stem cell differentiation needs to be developed.
Stem cell therapy refers to the use of stem cells for in vitro culture, proliferation, induction of differentiation, etc., to culture new, normal cells or tissues, and transplant them into the body to replace damaged or dead cells. With the emergence of eukaryotic toehold switches (eToeholds), some scholars have found that the eToeholds technology platform can also promote the in vitro differentiation of stem cells, guiding stem cells along developmental pathways to generate specific cell types for cell therapy and other applications. Transformation of stem and intermediate cells along many differentiated cell lineages is often not very efficient, and eToeholds technology can help enrich the desired cell types. At CD BioSciences, we can provide you with corresponding services based on the eToeholds technology platform.
eToeholds is an RNA-based programmable RNA element suitable for eukaryotes developed by inserting IRES into toehold switches. Using the established eToeholds technology platform, CD BioSciences can provide the design, optimization, and synthesis services of eToeholds RNA elements for specific sequences for scholars engaged in stem cell directional differentiation and stem cell therapy research.
CD BioSciences looks forward to providing you with eToeholds-based technical support in your research on directed induced stem cell differentiation. If you are interested in the application of eToeholds in the directed differentiation of stem cells, please feel free to contact us.